Endocrine Abstracts

Prostaglandins are important mediators of reproductive function. However, comparative differences in functional prostanoid receptors during gestation and postpartum are not fully explored. The aim of this study was to compare the responsiveness to PGF2α, PGE2, and U46619 in the rat uterine horn at late gestation and postpartum. Rats were sacrificed at late gestation (n=5–6) and at postpartum (n=5–6). Uterine horns were opened longitudinally, cleare...

Objectives: Congenital adrenal hyperplasia (CAH) is a rare condition caused by enzyme deficiency in cortisol biosynthesis. The aim of this study was to evaluate the burden of illness associated with child/adolescent and adult CAH.Methods: A structured, comprehensive literature review was conducted to identify articles describing the burden and treatment landscape of CAH. Literature databases (MEDLINE, Embase, the Cochrane Library and EconLit), websites a...